E123 |
E3 19 kDa protein |
NOB-1 |
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This is the ectromelia virus ortholog (Ectromelia virus E163 protein; Mousepox virus E163 protein) of the vaccinia virus A41L protein. E163 is a secreted 31 kDa glycoprotein that selectively binds a limited number of CC-Chemokines and CXC-Chemokines with high affinity. The protein has been shown to binds to the glycosaminoglycan binding site of CXCL10 and CXCL12. It also binds with high affinity with glycosaminoglycan, enabling E163 to attach to cell surfaces and to remain in the vicinity of the sites of viral infection (Ruiz-Argüello et al, 2008). Ruiz-Argüello et al (2008) have reported binding to CCL5, CCL8, CCL11,
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