DFF

[DNA fragmentation factor] This heterodimeric protein (40 and 45 kDa subunits) has been identified in the cytosolic fraction of HeLa cells. The 45 kDa subunit (DFF-45 [DNA fragmentation factor 45 kDa; 45 kDa DNA fragmentation factor]) is cleaved by Caspase-3 into two fragments that dissociate from the 40 kDa subunit. Murine ICAD [inhibitor of caspase-activated DNAse] and the 45 kDa subunit are considered homologous (Tang and Kidd, 1998). The 45 kDa functional isoform is being referred to as ICAD-L. The 35 kDa subunit is being referred to as DFFA or DFF1 [ ... ... ... ...
 
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Entry last modified: January 2014