DC-derived Ig-like receptor 2 |
D cells |
endogenous bioactive peptides |
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[Dendritic cell differentiation factor] This biochemically uncharacterized factor of approximately 30-35 kDa is produced by T-helper cells stimulated by IL2. It induces differentiation in primary cultures of monocytic leukemia cells towards cells resembling dendritic cells (Miyatani et al, 1994).
DCDF enhances HLA-DR expression by normal human monocytes and human monocytic THP-1 cells. DCDF significantly amplifies the T-cell stimulatory activity of monocytes in the allogeneic mixed leukocyte reaction. DCDF also enhances production of IL1-beta
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