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DARP

[dopamine releasing protein] DARP is a multisubunit glycoprotein involved in the development, recovery, and function of rat catecholaminergic systems as a potent regulator of dopamine release (Chang and Ramirez, 1988; Llano and Ramirez, 1994). DARP-36aa, (DFHKSEIAHRFNDLGEKMFKMLNLDMRNMYLQQKTS), is a peptide derived from the first 36 amino acids at the N-terminal sequence of DARP and shows strong sequence similarity with albumin.

DARP-36aa is one of the neurotrophic factors enhancing neuronal survival and axonal growth. It has been shown to be a selective promoter of cell survival and morphological development of cultured rat mesencephalic neurons (Smith and Ramirez, 2003).

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