CHCHD5

(approved gene symbol) [Coiled-coil-helix-coiled-coil-helix domain-containing protein 5]. The gene is encoded by C2ORF9 [chromosome 2 open reading frame 9].

CHCHD5 has been identified by Babbar et al (2018) who referred to it as CHTM1 [Coiled-coil Helix Tumor and Metabolism 1]. CHCHD5 is a protein of 12.9 kDa found in both cytosol and mitochondria. Cancer cells deficient in CHCHD5 have been shown to grow poorly in growth media lacking glucose and glutamine. CHCHD5 modulates lipid metabolism to promote cell survival under metabolic stress, and regulates the expression of genes important for fatty acid oxidation and synthesis. Increased levels of CHCHD5 are found in the majority of human ... ... ... ...
 
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Entry last modified: August 2020