CGNSNPKSC

(Cys-Gly-Asn-Ser-Asn-Pro-Lys-Ser-Cys) This peptide, referred to as GX1 peptide by the authors, has been identified by Zhi et al (2004) in a phage display screen for peptides that bind selectively to endothelial cells of human gastric cancer rather than non-endothelial cells. This homing peptide binds to the vasculature in xenotransplanted gastric cancer in nude mice and to human umbilical vein endothelial cells (Hui et al, 2008). A fusion protein of CGNSNPKSC with human TNF-alpha has been shown to be bioactive and to reach the tumour site faster than TNF-alpha ... ... ... ...
 
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Entry last modified: March 2015