CENP-B

[centromere protein B]. The protein is being referred to also as major centromere autoantigen B.

CENP-B (80 kDa) is one of several centromere-specific DNA-binding proteins (Earnshaw and Rothfield, 1985). The gene has been cloned by Earnshaw et al (1987).

CENP-B specifically binds a 17 bp sequence (the CENP-B box), which is required for centromere-specific nucleosome assembly and essential for the formation of functional minichromosomes Yoda et al, 1998; Ikeno et al, 1998; Ohzeki et al, 2002). CENP-B knock-out mice appear to be normal (Fowler et al, 2000; Hudson et al, 1998; Perez-Castro et al, 1998), and this has been attributed to the existence of functional CENP-B homologs.

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Entry last modified: January 2008