CDAP-4

[chemokine-derived antimicrobial peptide-4] CDAP-4 is a peptide derived from the C-terminal region of the chemokine CCL13. CDAP-4 corresponds to CCL13(57-75) and has the sequence KWVQNYMKHLGRKAHTLKT (Lys-Trp-Val-Gln-Asn-Tyr-Met-Lys-His-Leu-Gly-Arg-Lys-Ala-His-Thr-Leu-Lys-Thr).

This peptide assumes an alpha-helical configuration similar to that observed for other antimicrobial peptides and has good antimicrobial activity against Pseudomonas aeruginosa. The peptide is active also against Salmonella typhi, Salmonella typhimurium, Klebsiella pneumoniae, and Pseudomonas aeruginosa (Martinez-Becerra et al, 2007).

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Entry last modified: August 2017