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CCSP-2

[colon cancer secreted protein-2] This secreted and stably circulating serum protein has been identified by Xin et al (2005). The protein has been identified independently as AMACO. The approved gene symbol is VWA2 [von Willebrand factor A containing 2].


Expression of CCSP-2 is generally absent in normal colon and other normal body tissues. An average of 78-fold overexpression is observed in Stage II, III, and IV colon cancers, colon adenomas, and colon cancer cell lines. The protein is detectable in the blood of mice bearing human cancer xenografts transfected with epitope-tagged CCSP-2 and may be a suitable serum marker of early stage colon cancer (Xin et al, 2005).


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