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[Cocaine-and amphetamine-regulated transcript protein] The approved gene symbol is CARTPT [CART prepropeptide].

CART has been identified as a transcriptionally regulated gene in the striatum following acute administration of psychomotor stimulants (cocaine and amphetamine) (Douglass et al, 1995). The gene encoding CART has been identified by Douglass and Daoud (1996). Human CART shares 95 % amino acid identity with one of the 2 rat CART isoforms. Rats express a 102 amino acid long form and a 89 amino acid short form (Douglass et al, 1995), whereas humans only express the short form (Douglass and Daoud, 1996).

pro-CART is a substrate for neuroendocrine prohormone convertases (Stein et al, 2006; Dey et al, 2003). In the ... ... ... ... ... Subscribe to continue reading! ... ...


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