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BayK8644

[Bay K 8644]

[1,4-Dihydro-2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-3-pyridinecarboxylic acid, methyl ester]; [methyl 2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-1,4-dihydropyridine-3-carboxylate]

BayK8644 is a dihydropyridine derivative structurally related to the calcium channel antagonist Nifedipine. In contrast to Nifedipine, it functions as a calcium channel agonist. BayK8644 acts as a competitive antagonist of nifedipine in contractility experiments. It increases calcium channel activity by directly interacting with Calcium channels to promote entry of calcium ions (Ochi et al, 1984; Thomas et al, 1985; Schramm et al, 1983). BayK8644 is used primarily as a research tool to study calcium channel activities (Bechem and Schramm, 1987). For its application in the generation of cells with characteristics of ... ... ... ... ... Subscribe to continue reading! ... ...

 

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