AREs

[AU-rich elements]; also abbr. AURE; adenylate uridylate-rich elements] AREs are sequence elements of 50-150 nucleotides that are rich in adenosine and uridine bases. The AU-rich element core is a pentanucleotide sequence element, referred to also as mRNA decay element. This regulatory RNA sequence consists of one or more AUUUA tandem repetitions embedded in a uracil-rich region found in the 3' untranslated regions of a variety of mRNAs. Depending on sequences involved and modes of degradation imposed by these elements, AU-rich elements have been classified as Class 1 AREs (1-3 scattered AUUUA motifs), Class 2 AREs (multiple overlapping AUUUA ... ... ... ...
 
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Entry last modified: March 2019