ADAM14 |
ADAM17 |
TO-PRO 3 iodide |
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[a disintegrin and metalloprotease domain 15; ADAM metallopeptidase domain 15] This protein is known also as Metargidin [metalloprotease-RGD-disintegrin protein] or MDC-15 [metalloproteinase-like disintegrin-like cysteine-rich protein-15]. It is a member of the ADAM protein family.
The protein is expressed on the surface of a wide range of cells (Wu et al, 1997). Herren et al (1997) have shown that ADAM15 is expressed constitutively in cultured aortic smooth muscle and vascular endothelium and that ADAM15 is overexpressed in atherosclerotic lesions but not in normal aorta. Significant levels of ADAM15 are expressed in a variety of haematological malignancies, including leukemia
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