ADAM11 |
ADAM12S |
angora |
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[a disintegrin and metalloprotease domain 12; ADAM metallopeptidase domain 12] This protein is known also as Meltrin-alpha (approved gene symbol: MLTNA) (Inoue et al, 1998). It is a member of the ADAM protein family (Loechel et al, 1998). ADAM12S and ADAM12L are short and long forms, respectively, of the protein and arise by alternative splicing. ADAM12S is a secreted form of the protein consisting of pro, catalytic, disintegrin, cysteine-rich, and EGF domains, whereas the other variant is a membrane form.
The ADAM12 protein is synthesized as a zymogen in which the prodomain maintains the metalloprotease
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