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446-BCDF

[446 B-cell differentiation factor] This biochemically uncharacterized factor of approximately 32 kDa and a pI of 6.0 is produced and secreted by T-cells stimulated by antibodies directed against CD3.

The factor regulates terminal differentiation of B-cells (see also: BCDF), enhancing the synthesis of immunoglobulins by SAC-activated B-cells by a factor of 10-100.

This activity is not inhibited by antibodies directed against IL6 and is enhanced after passage over an affinity column with antibodies against IL6. Monoclonal antibodies generated against purified 446-BCDF do not inhibit differentiation of B-cells in response to IL2 ... ... ... ... ... Subscribe to continue reading! ... ...

 

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