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2B7

The 2B7 mRNA has been identified in rat smooth muscle cells. Sequence and tissue distribution data strongly suggest this mRNA to be identical with rat osteopontin.

2B7 mRNA expression in vivo in normal rat aorta and carotid arteries is 50-60-fold higher than in heart, and about 3-4 times the levels found in adult rat kidney. Significant levels of 2B7 mRNA are detectable in total RNA prepared from rat uterus and stomach, but not intestine (Giachelli et al, 1991).

Levels of 2B7 mRNA in carotid and aortic artery increase with age, and are elevated approximately 5-fold in the carotid artery 48 hours after balloon angioplasty.

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