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viral IL17

abbr. vIL17. This protein exhibits 72 % amino acid identity with human IL17 and 63 % with murine CTLA-8. It is encoded by HVS13 (orf13), an open reading frame from the genome of the T-lymphotropic Herpesvirus saimiri (Yao et al, 1995).

Recombinant vIL17 stimulates secretion of IL6 in fibroblasts, and costimulates T-cell proliferation.

Knappe et al (1998) have reported that vIL17 gene knock-out mutants of herpesvirus saimiri show normal viral replication, T-cell ... ... ... ... ... Subscribe to continue reading! ... ...

 

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