Tumor inducing factor-1 |
tumor-infiltrating natural killer cells |
Tc17/IFN-gamma cells |
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[tumor infiltrating lymphocyte]
abbr. TILs. Infiltration of ymphocytes into a tumor can be regarded as an expression of host immunity against the tumor (see also: immunoediting), but tumor infiltrating lymphocytes have little (CTIL; c = cytotoxic) or no cytotoxicity. It has been observed that cells resembling TILs, CIK (cytokine induced killer cells), can be generated which are even more cytotoxic. See also: myeloid suppressor cells.
TILs, which in humans include CD4(+) CD8(+) cells, are isolated directly from tumor tissues and can be expanded in vitro by culture in the presence of IL2
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