Tumor cell-derived collagenase stimulatory factor 2 |
Tumor cell-targeted cytokine gene transfer |
pro-inflammatory cytokines |
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these poorly characterised factors (15-48 kDa are obtained from the serum-free conditioned medium from human rhabdomyosarcoma A673 cells. These factors inhibit the growth of human tumor cells in soft agar and in monolayer cultures (see also: Colony formation assay). One activity has all the activiies of TGF-alpha. 90 % of the bioactivity consists of TGF-beta-1 and not TGF-beta-2 or TGF-beta-3. Although A673 cells are growth-inhibited by exogenous TGF-beta-1, TGF-beta-1 in the conditioned medium
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