tube formation assay |
tuberculoventral cells |
CG14375 |
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gene symbol: tub. Gene: CG10520. This Drosophila melanogaster gene has been identified by Letsou et al (1991) as a gene maternally required for embryonic dorsoventral polarity. The process involves activation of the kinase Pelle by Tube protein (Grosshans et al, 1994; Galindo et al, 1995). Tube protein contains an N-terminal death domain that allows Tube protein to interact with the death domain of Pelle (Schiffmann et al, 1999; Xiao et al, 1999). Towb et al (2009) have provided evidence that the Tube protein, Pelle, and IRAK proteins originate from a common ancestral gene. The function of Tube protein and Pelle in Drosophila
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