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trypanosome apoptotic factor

abbr. TAF (a term with multiple meanings). This protein is expressed by Trypanosoma brucei, the agent causing African trypanosomiasis (sleeping sickness). TAF is most likely a procyclin or one of its derivatives, glycosylphosphatidylinsitol-anchored proteins on the surface of procyclic (insect) form trypanosomes. TAF mediates cell death by apoptosis in mouse-brain and human-brain vascular endothelial cells (Pearson et al, 2000; Stiles et al, 2004).

For other entries pertaining to cell death mechanisms see also the Apoptosis and Cell Death Dictionary section of this encyclopedia. For other relevant entries see also the Pathogenicity/Virulence Factors Dictionary section of this encyclopedia.

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