TATI |
TAT-RasGAP(317-326) |
unc-5 homolog C |
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[Transactivator of Transcription] This viral gene is encoded by human immunodeficiency virus (HIV) and plays a central role in viral physiology. HIV Transactivator of Transcription (86 amino acids) is an RNA-binding protein, which interacts with a short nucleotide sequence called TAR (trans-activation responsive) that lies within the 5' LTR region of HIV mRNA transcripts. Binding of tat protein to the TAR sequence accelerates transcription of the provirus by cellular RNA polymerase II. The protein functions as a transactivator of gene expression
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