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smooth muscle derived extracellular matrix factor

abbr. SMEF (a term with multiple meanings). This biochemically uncharacterized factor has been described by Stenmark et al (1988). SMEF is produced by phenotypically altered smooth muscle cells as a result of hypoxic and/or pressure-induced vessel wall injury. SMEF stimulates or induces elastin and collagen synthesis in fibroblasts and endothelial cells. SMEF, or an associated activity derived from phenotypically altered smooth muscle cells, also induces elastin receptor expression on the cell surface and affects the chemotactic responsiveness of vascular cells.

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