small cells

This cell type - an unfortunate designation - has been identified in human and canine pancreas. They represent less than 1 % of total islet cells, are of a small size (7-10 microm) and highly quiescent. The cells have an immature morphology and are usually organized into small clusters. Small cells are positive for PDX-1, synaptophysin, insulin, glucagon, somatostatin, pancreatic polypeptide, alpha-fetoprotein. They do not express cytokeratin-19 and nestin. Insulin is secreted in a glucose-responsive fashion, but the cells do not respond to secretagogues like mature beta-cells ... ... ... ...
 
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Entry last modified: October 2006