sialostatin L2

A databank designation for Sialostatin L2 is Salivary cystatin-L2. Sialostatin L2 is a secreted salivary cystatin from the tick Ixodes scapularis closely related to Sialostatin L It inhibits cathepsin L and some other members of the cathepsin family (Kotsyfakis et al, 2007). Kotsyfakis et al (2010) have reported that sialostatin L2 - but not sialostatin L - facilitates the growth of Borrelia burgdorferi in murine skin.

Chen et al (2014) have reported that sialostatin L2, inhibits inflammasome formation during pathogen infection. Sialostatin L2 targets caspase-1 activity during host stimulation with the rickettsial agent Anaplasma phagocytophilum, a pathogen that causes macrophage ... ... ... ...
 
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Entry last modified: March 2015