senescence-associated secretory phenotype |
senescence marker protein-30 |
Cell death protein 7 |
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abbr. SA-T cells. These cells constitute a minor CD4(+) T-cell subpopulation with a phenotype of memory T-cells that constitutively express PD-1 [programmed death-1] (PDCD1) and CD153. SA-T cells progressively accumulate with age and exhibit characteristic features of cellular senescence, with defective T-cell receptor-mediated proliferation and T-cell cytokine production (IL2, IL4). Upon T-cell receptor stimulation, the cells secrete IFN-gamma, abundant atypical
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