ribosomal protein S12

approved gene symbol: RPS12. This protein is a component of the 40S subunit of ribosomes (40S ribosomal protein S12) (Kenmochi et al, 1998).

The cDNA encoding the human protein has been cloned by Hérault Y et al (1991). The deduced protein (132 amino acids) is 97 % identical to rat RPS12. Pogue-Geile K et al (1991) have reported overexpression in colorectal cancer.

Enhanced RPS12 expression has been shown to be related to metastasis of gastric cancer (Sun et al, 2005). Silencing of RPS12 expression by RNAi leads to increased cell death by apoptosis of gastric cancer cells ... ... ... ...
 
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Entry last modified: April 2015