ribosomal protein L17 |
ribosomal protein L23 |
LFRLIKSLIKRLVSAFK |
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approved gene symbol: RPL22. This protein is a component of the 60S subunit of ribosomes (60S ribosomal protein L22) (Kenmochi et al, 1998). For gene structure see also: Yoshiyama et al (2002). Ribosomal protein L22 is not required for core ribosome functions and functions as an RNA-binding component of the 60S ribosomal subunit (Rao et al, 2012).
Knock-out mice lacking expression of the ribosomal protein are viable, fertile, and grossly normal. However, they have a specific block in the development of Alpha-Beta T-cells (Anderson et al, 2007). Rao et al (2012) have reported that generated monoallelic, germline inactivation of ribosomal protein L22 predisposes T-lineage progenitors to transformation. Ribosomal protein L22 is inactivated in approximately 10 % of
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