rhabdomyosarcoma homing peptide 2 |
RHAG |
interleukin-6 receptor |
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Two peptides have been identified by phage display-based screening for peptides that bind specifically to rhabdomyosarcoma cells. RMS-I [rhabdomyosarcoma homing peptide 1] (CQQSNRGDRKRC) and RMS-II [rhabdomyosarcoma homing peptide 2] (CMGNKRSAKRPC) bind to rhabdomyosarcoma and to other tumour cell lines, but not to normal skeletal muscle cells and fibroblasts. RMS-I contains the integrin-binding motif RGD and its binding is blocked by an antibody against integrin-alpha-V / integrin- beta-3. RMS-II
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