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relaxin-like peptide family

The relaxin-like peptide family belongs to the insulin superfamily and consists of various secreted peptide hormones with high structural similarity (two-chain structure and three disulfide bonds in a disposition identical to that of insulin) but low sequence similarity (Wilkinson et al, 2005; Tregear et al, 2009). Members of this family are

relaxin 1,

relaxin 2

relaxin 3,

and the insulin-like peptides

INSL3, (RLF [relaxin-like factor])

INSL4 (EPIL [early placenta insulin-like peptide] or placentin),

INSL5

INSL6.

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