quasi-regulatory T cells

abbr. qTregs. This term has been coined to refer to a subset of epithelial cells in pancreatic cancer that mimics the phenotype and function of regulatory T-cells and contribute to enhanced immune evasion, angiogenesis, and metastasis of pancreatic cancer. The cells show upregulated expression of FOXP3, a master transcription factor of regulatory T-cells, and downregulation of transcription factor EHF, thought to play a role in regulating epithelial cell differentiation and proliferation. The cells are characterised by the overexpression of PDL1 [programmed death-1 ligand 1] and loss of E-cadherin ... ... ... ...
 
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Entry last modified: March 2024