programmable base editing |
Programmed cell clearance |
EC1.16.3.1 |
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abbr. PCMOs. These cells have been obtained after treatment in vitro of human peripheral blood monocytes with M-CSF and IL3 and interleukin 3 for 6 days (Ruhnke et al, 2005). Programmable cells of monocytic origin are stem cell-like cells. They go through a process of dedifferentiation but retain monocytic characteristics, notably CD14 expression, a monocyte-specific methylation pattern of the CD115 gene, and expression of the transcription factor PU.1. Ungefroren et al (2010) have reported that the generation of programmable cells of monocytic origin involves partial repression of monocyte and macrophage
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