p53-inducible cell-survival factor |
p53-regulated apoptosis-inducing protein 1 |
homeostatic thymus hormone-beta |
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[p53-regulated receptor for death and life 1] This protein, which is identical with UNC5B (UNC5H2) has been identified by Tanikawa et al (2003) as a target of p53. p53RDL1 mediates p53 dependent cell death by apoptosis. Interaction of p53RDL1 with its ligand, Netrin-1, blocks p53 dependent apoptosis. The authors have suggested that p53 might regulate the survival of damaged cells by balancing the regulation of Netrin-1 p53RDL1 signaling, and cell death through cleavage of p53RDL1 for apoptosis.
For other entries pertaining to cell death mechanisms see also the Apoptosis and Cell Death Dictionary section of this encyclopedia.
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