orf virus IL10
[ORFV-IL10, ovIL10] This protein, encoded by orf virus gene ORFV127, shows strong homology to mammalian interleukin IL10) and viral encoded IL10 species of herpesviruses, Epstein-Barr virus, and equine herpesvirus. The C-terminal two-thirds of the orf virus protein are identical to ovine IL10. orf virus IL10 is a virulence factor as shown by in vivo attenuation of viruses engineered to lack orf virus IL10 (Fleming et al, 2007).
The functional activities of orf virus IL10 are the same as ovine IL10. The protein stimulates proliferation of mouse
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