NOD27 |
Nod-like receptors |
CMRF35-like molecule-3 |
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A murine gene identified by its inactivation through retroviral insertion. nodal encodes a secreted protein belonging to the TGF-beta protein superfamily (see also: gene family). The protein is about equally related to Activin A and BMP (bone morphogenetic proteins).
Disruption of the nodal gene in knock-out mice leads to a failure to form the primitive streak in early embryogensis, a lack of axial mesoderm tissue, and an overproduction of ectoderm and extraembryonic ectoderm. For the zebrafish ortholog nd conserved functions in left-right patterning see: Southpaw.
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