necroapoptotic cell death |
Necroinflammation |
DFNB59 |
||
This term has been suggested by Zhao W and Hu Z (2010). It specifically pertains to the release of factors by damaged cells during cell death by necrosis. This pathway of growth factor or cytokine activity is thought to signal tissue damage with the released factor performing the function of an alarmin (see: DAMP [damage-associated molecular patterns]). Zhao W and Hu Z (2010) have suggested that IL33 released by necrotic cells may function as a danger signal in a necrocrine pathway as IL33 is translated without a signal sequence
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