Manchester inhibitor |
mandibular organ-inhibiting hormone 1 |
Growth factor receptor-bound protein-3-3 |
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abbr. MOIH. This neuropeptide, termed also MOIH-1 [mandibular organ-inhibiting hormone 1], is a neurohormone of 78 amino acids synthesized and secreted from the X-organ-sinus-gland complex of the eyestalk in the crab Cancer pagurus and regulates the biosynthesis of the putative crustacean juvenile hormone, methyl farnesoate. The hormone shows significant sequence similarity with molt-inhibiting hormones (for a general overview see also: Webster et al, 2012). MOIH-2 [mandibular organ-inhibiting hormone 2] is a variant that differs from MOIH-1 in a single amino acids (Wainwright et al, 1996). Both peptides
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