lysophagy |
lysophosphatidylserine |
LTBP4L |
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This activity (lysophospholipase D; abbr. lysoPLD) is found in the conditioned medium of murine adipocytes and human adipose tissue explants. Undifferentiated pre-adipocytes secrete less of this activity than differentiated adipocytes and its expression is upregulated considerably during adipocyte differentiation of 3T3F442A-pre-adipocytes (Gesta et al, 2002; Ferry et al, 2003).
The enzyme generates physiologically active lysophosphatidic acid from its preferred substrate, lysophosphatidylcholine (Tokumura et al, 2002; for overview see also: Perrakis and Moolenaar, 2014). Lysophospholipase D purified from human
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