laminin-alpha-5 cryptic peptide
This cryptic peptide (AQARSAASKVKVSMKF) is derived from the laminin-alpha-5 (approved gene symbol LAMA5), which is a subunit of several laminins (Laminin-10 subunit alpha, Laminin-11 subunit alpha, Laminin-15 subunit alpha). The cDNAs have been identified independently as KIAA0533 and KIAA1907.
Adair-Kirk et al (2003) have reported that the incubation of mouse macrophages with this peptide increases the expression of the metalloproteinases MMP-9 and MMP-14, but not MMP-2, MMP-3, MMP-7,
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