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label-retaining cells

[label-retaining cell]

This term pertains to cells that have been treated in vivo or in vitro with 3H-thymidine or 5-bromo-2'-deoxyuridine and retain this label for long periods of time. The label as such can be taken as a simple indicator of the proliferative history of a cell. Quiescent cells that do not proliferate retain the label, and this may be indicative of these cells having characteristics of stem cells (Braun and Watt, 2004; Terskikh et al, 2012), or cancer stem cells (Schillert et al, 2013). Long-term label retaining cells divide actively during tissue development and remain quiescent at homeostasis. These two properties have been attributed to adult stem cells.

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