killer CD4 cells

also: CD4(+) killer T-cells, CD4(+) cytotoxic T-cells; abbr. CD4(+) CTLs. [CD4(+) cytotoxic T-lymphocytes] This population of T-cells, which is characterised by the expression of CD4 rather than CD8 as found in cytotoxic T-cells, has been observed in the context of virus infections in vitro (Lukacher et al, 1985; Jacobson et al, 1984; Appay V et al, 2002; Adhikary et al, 2006; Jacobson S et al, 1984; Hou S et al, 1993). Their existence has been confirmed in vivo (Erb P et al, 1990; Jellison et al, 2005) The cells can act to reduce a secondary infection by directly killing infected cells. Cell killing may be mediated by Perforin ... ... ... ...
 
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Entry last modified: October 2022