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ken

[ken and barbie] This Drosophila melanogaster protein is encoded by gene CG5575. It is the fly ortholog of the BCL6 oncogene. The ken gene was identified originally in a screen for mutants causing male sterility. Ken mutants lack external genitalia (Castrillon et al, 1993). Ken shares a domain structure with other known transcriptional repressors such as the presence of a BTB/POZ domain and a C-terminal zinc finger domain (Lukacsovich et al, 2003) and has been shown to act as a selective inhibitor of a subset of JAK-STAT targets (Arbouzova et al, 2006). Arbouzova et al (2006) have reported that ken enhances the adult eye overgrowth phenotype of mutations in the ... ... ... ... ... Subscribe to continue reading! ... ...

 

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