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isoleucyl-tRNA synthetase

approved gene symbol: IARS; referred to also as IARS1 [isoleucine tRNA ligase 1]; abbr. also IRS, IleRS, ILRS; EC6.1.1.5 in the nomenclature of enzymes.

This Aminoacyl-tRNA synthetase plays a critical role in translation by charging tRNAs with the cognate amino acid (for overview see: Carter, 1993; Ibba and Soll, 2000). The cDNA sequence has been reported by Nichols et al (1995).


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