COPE Media Kit


Cope Home
Previous entry:
immunoreceptor tyrosine-based inhibitory motif
Next entry:
immunoregulatory microRNAs
Random entry:
H7365
Search COPE:

immunoreceptor tyrosine-based switch motif

[immunoreceptor tyrosine-based switch motifs]

abbr. ITSM. The ITSM motif is a stretch of amino acids (TxYxxV/I) identified by virtue of its ability to bind to the small adaptor SH2D1A [Src homology 2 domain-containing molecule 1A] (SAP; Signaling lymphocytic activation molecule-associated protein, which is defective in X-linked lymphoproliferative disease) (Sidorenko and Clark, 2003). The ITSM, defined originally in CD150, recruits the tyrosine phosphatase SHP-2 [Src homology region 2 domain-containing phosphatase-2] to the CD150 cytoplasmic tail. In the presence of SH2D1A, the ITSM recruits SHIP [SH2-containing inositol phosphatase] to CD150 ... ... ... ... ... Subscribe to continue reading! ... ...

 

Content view restricted !

COPE - with 54500+ entries the most comprehensive cell-to-cell communication knowledge base

Extensive In-depth and In Context Information covering terminology, nomenclature, concepts, strategies & complexities of cellular communication, including Acute phase proteins | Angiogenesis | Antimicrobial & host defense peptides | Apoptosis & other forms of cell death | CD antigens | Cell lines | Cell reprogramming | Chemokines | Cryptides | Cytokines & Growth factors | CytokineTopics | Eukaryotic cell types & expression profiles | Hematopoiesis | Hormones | Inflamation & inflammatory mediators | Innate Immunity | Metalloproteinases | Microvesicles / Microparticles | Moonlighting proteins & cryptides | Neuropeptides | Non-coding RNAs | Pathogenicity & Virulence Factors | Pattern recognition receptors | Peptide sequences | Protein domains | Regulatory peptide factors | Viroceptors | Virokines and more.

Full COPEing for subscribers:

Access to Alphabet bar, Freetext search, Leafing/browsing functions, Internal Backlinking, Topic-specific introductions, Topic-specific integrated subdictionaries, Scientific references with PubMed links

with a 15 USD/month subscription at Cells-Talk.com

See example pages at the bottom of the Cells-Talk.com home page
THE SMART ONES COPE
The others just sisyphos around

 

Copyright © 1997-2021. All rights reserved by Dr H Ibelgaufts, the author of COPE - Cytokines & Cells Online Pathfinder Encyclopaedia

ENTRY LAST MODIFIED: April 2012



 
 
SUPPORT COPE | Intro | Subdictionaries | New Entries | Contribute data | COPE Credentials
# A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

              Created, developed, and maintained by Dr H Ibelgaufts              
About the author of COPE
  |    Contact COPE   |    Terms & Conditions


U L T R A   P O S S E    N E M O   O B L I G A T U R



cope.cgi Version 1.41 [08.12.2020]. (c) JI. Powered by Perl 5.028001. key=26789