Immunoglobulin production stimulating factor-2-beta |
immunoglobulin superfamily containing LRR |
CG14375 |
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This protein, which is homologous to immunoglobulin lambda light chain, is expressed by human pre-B-cells, which produce immunoglobulin heavy chains but do not produce immunoglobulin light chains. Sequence analysis shows that the C-terminal half of the encoded protein (214 amino acids) is highly homologous to immunoglobulin lambda light chain joining and constant region, while the amino-terminal end does not share homology with variable regions. Unlike immunoglobulin genes, the gene encoding immunoglobulin-related protein 14.1 does not undergo rearrangement prior to expression. The expression of immunoglobulin-related protein 14.1, which is most likely the immunoglobulin omega polypeptide, is limited to pre-B-cells.
In the nomenclature of CD antigens
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