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hypertension-related gene-1

abbr. HRG-1. This gene has been identified in cultured vascular smooth muscle cells of Wistar-Kyoto and spontaneous hypertension rats (Chen et al, 1997). The expression of this gene is lower in spontaneous hypertension rat than Wistar-Kyoto rat. Vascular smooth muscle cell proliferation is inhibited by hypertension-related gene-1 (Chen et al, 2001). The gene has been renamed HSG [Hyperplasia suppressor gene] following the observation that overexpression suppresses serum-evoked vascular smooth muscle cell proliferation in culture. HSG is identical with mitofusin-2.

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