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hybrid cytokine

[hybrid cytokines]

This term, like the term composite cytokine, has been used to describe naturally occurring growth factors or cytokines that are composed of the bioactive components of two unrelated cytokines. An example is PPBSF [pre-pro-B-cell growth stimulating factor], which is a heterodimer of IL7 and a variant beta-chain of hepatocyte growth factor (HGF). Other examples are IL23, IL27, IL35.

For genetically engineered proteins combining coding sequences of two proteins (Harlequin molecules and others) see also: muteins.

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