hematopoietic stem cell chemotactic factor |
hematopoietic stem cells |
BP5 |
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often just niche. This collective term pertains to the specific permissive regulatory miroenvironment in the non-hematopoietic bone marrow that consists of multiple cell types including vasculature, bone, adipose tissue, and fibroblast-like bone marrow stromal cells. This niche is more than just an anatomical site: without the support of the heterogeneous group of cell types - frequently collectively referred to as niche cells - stem cells cannot maintain their unique properties such as self-renewal, quiescence, differentiation, adhesion, long-term multilineage repopulation ability, expansion, and migration under physiological and pathophysiological conditions (e.g., acute stress conditions requiring increased
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