guidance receptors |
guidepost neurons |
Asporin |
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[guidepost cell]
The concept of guidepost cells has been developed from studies of stereotyped routes taken by pioneer axons that eventually become a major adult nerve trunk along the length of the limb in grasshoppers (Bentley and Caudy, 1983; Caudy and Bentley, 1986; Meier and Reichert,1991).
Guidepost cells may be neuronal cells (guidepost neurons) or non-neuronal cells. They are specific nonadjacent cells that facilitate axon extension across regions of low cell-substratum adhesivity or spaces between guidepost cells (Hammarback and Letourneau, 1986). Guidance or navigation cues provided by guidepost cells mark a path along which the pioneers grow (Palka et al, 1992). Promotion or inhibition of synapse formation may include direct cell-cell interaction but also secreted guidance cues
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