frizzled-8 |
frizzled-8c |
B2 |
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frizzled-8(541-549), abbr. FzD8(541-549), is a sialoglycopeptide with the amino acid sequence TVPAAVVVA (Thr-Val-Pro-Ala-Ala-Val-Val-Val-Ala), corresponding to one of the transmembrane regions of frizzled-8 (Keay et al, 2004). This peptide has been identified previously as APF [Antiproliferative Factor], which is elevated in the urine of patients with interstitial cystitis. APF is an inhibitor of HB-EGF production and inhibits the proliferation of normal bladder epithelial cells and cancer
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